Simmonds disease Treatment

Treatment for Simmonds disease is Hormone replacement therapy and etiological treatment.

Hormone replacement therapy:
Add the target gland hormone until approach to normal hormone secretion.

1. Adrenocorticotropic hormone:
Cortisone, hydrocortisone 12.5-37.5mg / d; or prednisone 5-7.5mg, two hours early morning and the afternoon using it, the morning with 2 / 3 the volume of the afternoon with 1 / 3 volume. Case of stress situations (such as infection, surgery, trauma, childbirth, etc.) should be increased 2-3 times the amount of temporary, severe crisis by dealing with. Patients with pituitary dysfunction, general no use salt corticosteroids.

2. Thyroid hormone:
L-thyroxine tablets from 50ug / d to start, gradually increase to 100-200ug / d. Thyroid tablets may also be oral. To prevent the increase of adrenocortical insufficiency, should be combined by glucocorticoidin before medication.

3. Sex hormone and gonadotropin:
1) man: testosterone propionate 25-50mg, intramuscular injection, 1-2 times / week, or testosterone enanthate 200mg, intramuscular injection of 3-4 times / week. In order to facilitate sperm production can be combined HMG and HCG, intramuscular injection of 1-2 teams next day the former, treatment for more than 3 months; the latter were injected 2-3 times per week, per 1000IU.

2) woman: before menopausal use artificial cycle therapy. Phenol ethylene oral 0.5-1mg / d, once a 24 days, the first 21-25 days of added progesterone 10mg, intramuscular injection, after the menstrual withdrawal. Can also be added with a small dose of androgen, such as testosterone propionate 12.5mg, intramuscular injection, 1-2 times / week.

The etiological treatment:
Pituitary tumor resection by radiotherapy or surgery, should surgical treatment of hypothalamic tumors.