Simmonds disease Causes
Simmonds disease have many causes, the common causes include:
1. Avascular necrosis of the anterior pituitary: it is the common causes of Simmonds disease. Postpartum pituitary necrosis called Sheehan syndrome. Pituitary hyperplasia hypertrophy in the late pregnancy, when massive bleed after childbirth, lead to low blood pressure, cause small artery spasm in pituitary gland, result in Avascular necrosis of the anterior pituitary. Diabetic microangiopathy may also cause pituitary ischemic infarction.
2. Pituitary and hypothalamic tumors. In particular, chromophobe cell tumors and craniopharyngiomas.
3. Invasive pituitary disease, leukemia, sarcoidosis, etc..
4. Autoimmune hypophysitis.
5. Radiotherapy and chemotherapy: cause injury of pituitary and hypothalamus. Pituitary resection; pituitary abscess, tuberculosis, encephalitis, meningitis, and other infection diseases.
6. Idiopathic: most is the lack of a single hormone. As a result of defects in the hypothalamus, so that the lack of hormone secretion, the most common is gonadotropin (Gn) or growth hormone (GH).