Reflux esophagitis is belong to gastroesophaeal reflux disease (GERD), it is pathological changes of esophageal mucosa inflammation, erosion, ulcer disease and fibrosis that caused by foods reflux from the stomach and duodenal to esophageal. Gastroesophageal reflux contain physiological and pathological. All people have normal physiological reflux, reflux esophageal objects can be quickly removed, there will be no esophageal mucosal injury.
When the occurrence of reflux esophagitis, the throat have foreign body sensation, there may be white or light yellow granular solid odor, bad breath. Visible to the naked eye bleeding esophageal mucosa, edema, hemorrhage easily brittle. Acute esophagitis off when epithelial necrosis, the formation of superficial erosion and ulceration. In severe cases, the cortex may shed a whole, but generally not more than muscularis mucosa. Chronic esophagitis, the mucosa erosion fibrosis can be made fat, and crossed the muscularis mucosa and involving the entire esophageal wall. Esophageal mucosal erosion, ulcers and repeated by the formation of fibers can be cicatricial esophageal stenosis occurred. Squamous epithelium can be seen under the microscope of the basal cell hyperplasia, breast wear surface extending to the epithelial layer, and accompanied by vascular hyperplasia, lamina there is neutrophil infiltration. Stenosis in the esophagus, the muscularis mucosa or scar formation may be. Severe esophagitis, the mucosa can be seen is the destruction of the grass-roots level, and due to excessive ulcers, ulcers of the squamous cell edge can not be repaired through the re-epithelization ulcer, and like metaplasia known as Barrett esophagus. Ulcer that occurred on Barrett epithelium is also called Barrett's ulcer.
Reflux esophagitis can complicate esophageal stenosis, hemorrhage, ulcers, and reflux of gastric juice can erode pharynx, vocal cords and trachea caused by chronic pharyngitis, vocal cord inflammation and chronic bronchitis, Delahunty called clinical syndrome. Gastric reflux and respiratory tract can be caused by inhalation of aspiration pneumonia. GER and recurrent asthma, cough, night-time apnea, angina-like chest pain related.