Patent ductus arteriosus cause

Genetic is the main cause of Patent ductus arteriosus. In the fetal period, many factors that impact on heart embryonic development may cause heart defects, such as pregnant woman suffering from rubella, influenza, mumps, Coxsackie virus infection, diabetes, hypercalcemia, such as exposure to radiation; pregnant woman to take anti-cancer drug.

Embryology and pathogenesis of Patent ductus arteriosus: Fetal ductus arteriosus from the back of the sixth branchial arch aortic development from fetal blood circulation constitute aorta, pulmonary artery between the physical channel. Fetal lung collapse all vesicles do not contain air, and no respiratory activity, and pulmonary vascular great resistance, so the blood from the right ventricle, the lungs are unable to enter the oxygenation cycle. as a result of pulmonary artery pressure higher than the aorta, so most of the blood into the pulmonary artery to aortic arterial inflow catheter via the umbilical artery of placenta, in the blastoderm with the metabolism of maternal blood exchange, and then flows back into the fetal umbilical vein blood circulation.