Osteosarcoma is diagnosed on the basis of medical history, signs, X-ray films and CT, biopsy.
1. Multiple 15 - 25-year-old young, good-fat in the limbs end of the backbone of long-tube. The most common upper and lower parts of the knee.
2. The main symptoms were local pain, intermittent dull pain early and rapidly to persistent pain, especially at night.
3. Local skin temperature high, intravenous, mass rapid growth, pain, tremor and blood vessels may be noise, can be rational sick fractures, joint dysfunction.
4. Systemic toxicity, loss of appetite, weight loss, the final failure, cachexia occur.
5. Anemia, elevated leukocyte, erythrocyte sedimentation rate block, alkaline phosphatase increased Mei.
6. X-ray. Confirmed diagnosis for Osteosarcoma is depend on X-ray, characteristics is shown below:
Metaphysis of long bones are starting from osteosarcoma of bone, in bone marrow produce damage or irregular sclerosis. The gradual expansion of lesions in general, occupying the majority of stem epiphyseal area, to the backbone direction. But not very long.
Oncology at the same time or around the side to the side of expansion, cortical destruction, periosteal invasion to set off under the periosteum, resulting in proliferative periosteal sclerosis, cortical bone formation and parallel vertical layered cortex or the "needle radiation"-like shadow.
The further development of lesions, tumor perforation of the periosteum of invasive soft tissue to form a soft tissue mass, in which tumors of various degrees of new bone. At this point, the tumor, the residues near the border under the periosteal reaction was triangle triangle Codman said.
Osteosarcoma joints generally do not violate, in the epiphyseal plate did not heal before the cartilage sarcoma for the resistance, not to invade and epiphysis.
The differentiation and maturation of new bone formation of the sarcoma Obviously, less bone destruction, into a mainly Hyperosteogeny osteogenic osteosarcoma, and its generally low degree of malignancy, slow growth.
Differentiation of primitive sarcoma little new bone growth, significant bone destruction, into a mainly osteoclastic osteolytic osteosarcoma, and its degree of malignancy is generally higher, more rapid growth. In fact, most cases of mixed type.
