Osteosarcoma Causes

Osteosarcoma is common caused by radioisotope radium and trauma. Occurred in long bone lesions, multiple epiphyseal dry at the Ministry of minority in the backbone of the middle of the rapid tumor development along the canal, on the one hand to epiphyseal end of the spread. On the other hand, the tumor occasionally spread to the backbone. In addition, the tumor is rapidly outward development, and invasive cortical Hastelloy systems within the blood vessels caused by dystrophy, cortical bone was destroyed, the tumor soon reach subperiosteal and adjacent muscle tissue from outside intrusion.

In addition to genetic, exposure to radioactive substances, virus infection is other causes of Osteosarcoma. Malformation can also be secondary to osteitis, bone fibrous dysplasia, and another Osteosarcoma causes is benign tumors malignant.

Histological osteosarcoma is characterized by proliferation of spindle tumor cells directly produce osteoid or immature bone matrix. Osteosarcoma from primitive progenitor cells, which have the potential characteristics of cells can differentiate into bone, cartilage and fiber, so Osteosarcoma of bone in addition to malignant cells, there are chondroblastoma and fibroblast cells. Under the three kinds of cells, the number of components, and the causes, it can be divided into osteosarcoma Osteoblastoma type (osteoblasts), chondroblastic cell type (cartilage) and type of fibroblasts (fibroblast).

1) Osteoblastoma type: The main obvious from a vicious atypia Osteoblastoma composition, the formation of more bone tumors and bone tissue, with varying degrees of cell differentiation, and some more mature differentiation, atypia was not obvious to form more bone tumor, while others are poor differentiation, tumor cell atypia is clear, easy to see nuclear fission, the formation of bone tumors and less bone-like tissue.

2) chondroblastic type: tumor tissue, in addition to osteoblasts, the half of chondrosarcoma structure, tumor cells can be seen at the same time direct the formation of bone tumors and bone tissue.

3) fibroblast-based: spindle-shaped tumor cells, arranged in spoke-like vehicles, which shows that direct the formation of tumor cells of bone tumors and bone tissue.