Osteopetrosis Diagnosis

Osteopetrosis diagnosis is depends on X-ray, also be found through family history. Sometimes, through biochemical and immunological tests combined with CT, X-ray film to diagnose its type. Malignant type for complex clinical manifestations, diagnosis is more difficult, attention to identification Osteopetrosis or thalassemia, leukemia, dental and bone marrow fibrosis syndrome.

In cases where the period since the emergence of anemia in infants with growth retardation, poor nutrition, liver, spleen, lymph nodes, particularly splenomegaly and long-term effects of poor anti-anemia treatment, the need to diagnose Osteopetrosis. When the sense of bone biopsy punctune is hard, into the needle, Needle difficult, not easy to successfully pumped dry, they should be more alert to the timely shooting whole body bone X-ray film, because X-ray examination can confirmed diagnosis for Osteopetrosis.

1) the basic X-ray showed: wide uniformity, increased bone mineral density, bone sclerosis, trabecular bone coarsen, fuzzy, cortical thickening and medullary stenosis even disappear. The Court had three cases of osteopetrosis patients, due to fracture, interlocking intramedullary nail For fixed lines, due to the disappearance of medullary cavity, bone sclerosis, switch plate or dynamic condylar plate fixation, bone mineral density increased significantly even symmetry, the primary aim of the limbs, ribs and pelvis more apparent.

2) bone in bone: seen mainly in the metacarpophalangeal, metatarsophalangeal joint and the ribs and so on, bone in bone showed more obvious boundary dense bone island.

3) sandwich vertebra, the vertebral body from top to bottom as a result of the formation of cartilage is rich in blood vessels, in the lack of calcium absorption, bone deposition over the category. Osteoid on the osteoclasts has obvious inhibitory effect, while the absence of such a type of central vertebral bone, they are eroded by osteoclasts, the formation of upper and lower vertebra and the middle of high-density low-density.

4) ring-like changes in iliac wing. Ray through the bone with a more normal regions, and dense with the existence of a large number of non-functional osteoclasts.

5) thickening of the skull vault were hardened skull base to the skull base most obvious Hyperosteogeny.