Osteitis deformation (Paget's disease) Treatment

Osteitis deformation no need to treatment without symptoms. Salicylate and non-steroidal anti-inflammatory drugs can be used to reduce the pain. Drug therapy can affect the flow of inorganic ions and inhibit the activity of bone cells, it has therapeutic effects. Appropriate indications for chemotherapy: 1) the pain must be clearly and Paget disease rather than other diseases (such as osteoarthritis). 2) to do orthopedic surgery prior to drug treatment to prevent or reduce bleeding.

1. Drug treatment
1) Calcitonin: the amount of the more general, and start every day salmon calcitonin subcutaneously or intramuscularly 100U (40mg), later renamed the next few weeks 100U. Bone disease gradually disappeared after a week to 100 ~ 200U. In at least one course of treatment, sometimes long-term application.
2) phosphate: EHDP (disodium ethane-1 hydroxyl-1 ,1-diphosphate; disodium etidronate), oral 20mg / (kg d), use time typically 0.5 ~ 1 year. Phosphate should be combined with calcitonin.
3) Plicamycin: with lower serum calcium, inhibition of bone metabolism. Intravenous infusion of 15 ~ 25μg / (kg d), once a 7 to 10 days, no significant side-effects may continue, where appropriate, the application can also be a smaller dose once a few weeks, or one with a larger dose every 1 ~ 2 weeks intravenous times. The main side effects of this drug are gastrointestinal reactions.
4) Sodium fluoride: As adjuvant therapy, such as general and vitamin D combination.

2. Surgical treatment.
Basilar invagination could use suboccipital craniotomy. There is traffic when possible hydrocephalus ventricle - jugular vein shunt, foramen laminectomy and angioplasty are able to remove the spinal cord or nerve root compression symptoms. Long bone fracture treatment should be adjusted accordingly, there is deformity osteotomy surgery, and so on are viable.