Osteitis deformation Symptoms and Complication
Osteitis deformation (Paget's disease) usual be found in middle-aged and old. Anyone have asymptomatic. When the majority of patients have the symptoms include: back pain, femur, skull or tibia and fibula pain, stubborn and strong headaches and skull damage, into the skull base or intracranial hypertension related. Increased skull to bone surface is obvious. Spinal deformities may be tonic or more seriously, has a hunched back, knee varus, external rotation of lower limb, tibial flexion, hip and other joint ankylosis. Lesion was often pathological fracture happened. Vertebral deformity of spinal cord compression can cause paraplegia. Skull lesions in the skull base can lead to disease. Hip disease when abnormal gait, barriers to activity. Cardiovascular calcification is caused by heart valve dysfunction, hypertension and congestive heart failure. Associated with osteosarcoma, the local swelling, pain and tenderness obvious.
Complications of Osteitis deformation (Paget's disease) mainly include fractures, low back pain, joint disease, cardiovascular abnormalities, deafness, and eye and skin lesions such as hyperuricemia.
1. Fractures. There are 3 types of fracture: the crack fracture, long bone fracture and vertebral compression fractures. Minor trauma or may occur without trauma, nonunion rate was 40%.
2. Low back pain. Are probably small secondary arthritis due to pathological fracture or.
3. Articular lesions. Osteitis associated with the deformation of the joint section of the abnormal lesions, degenerative joint disease, cartilage calcium deposition and pseudo-gout, calcification of the joints around go far.
4. Cardiovascular abnormalities. Osteitis deformation involving more than 30% of bone or the skull may be involved alone appears to increase cardiac output, vascular calcification cause obstruction.
5. Deafness. Skull plate hyperplasia narrow channel can cause the skull base. Cranial nerve compression, and its good for the hair part of petrous bone, causing sensory hearing loss, middle ear ossification and chronic inflammation, such as lesions, or cause optic disc edema, ocular lesions, exophthalmos, optic atrophy and blindness .
6. Hypercalcemia and hypercalciuria. Only seen in some lesions are not extensive and long-term activities. In addition, some patients too much uric acid can lead to hyperuricemia.
7. Malignant lesions. Concurrent osteitis deformation sarcoma accounts for about 1%, the majority of osteosarcoma, but also fibrosarcoma or other types of sarcoma, giant cell tumor of bone secondary rare.