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Osteitis deformation (Paget's disease) Diagnosis

Diagnosis for Osteitis deformation (Paget's disease) use laboratory test include: ALP increased blood contribute to the diagnosis of disease, but can not be ruled out of their normal possible. Some patients increased serum calcium, phosphorus slightly. Blood levels of bone alkaline phosphatase and urinary hydroxyproline increased. Calcium, phosphorus, magnesium and PTH normal.

1. Blood alkaline phosphatase (ALP) serum ALP levels and disease extent and degree of disease activity. Bone lesions are small (about 10%) ALP normal. ALP increased when skull lesions. Complications such as osteosarcoma, ALP can be dramatically increased, acid phosphatase and 5 - nucleotide enzymes can also be increased.

2. Urine hydroxyproline (HYP) at low gelatin diet healthy at the time of urinary excretion of hydroxyproline is less than 50mg / d, and inflammation in patients with Paget bone remodeling because of their strong prolyl urinary hydroxyproline acid excretion may be up to 2000mg / d.

3. Calcium, phosphorus, magnesium and PTH normal. About 15% ~ 20% of patients with bone remodeling due to increased demand for calcium, serum PTH cause calcium to accelerate the rise. Bone involvement in patients with a wide range of parts, or with primary hyperparathyroidism have hypercalcemia and hypercalciuria.

Osteitis deformation (Paget's disease) is diagnosed by Other examination:

1. X-ray of the performance of more complex, can be summarized into the following points:

  • bone damage, sparse rough trabecular bone, with the limitations of osteoporosis, the late cortex and medulla of the bone cavity boundaries unclear, such as network structure of fuzzy shape;
  • backbone thickening, swelling, bending deformation;
  • skull limitations of osteoporosis, both inside and outside the plate boundaries disappear, fuzzy craniosynostosis, the skull increases;
  • vertebral body shape and the side fence was box-like change;
  • osteolytic lesions of long bones were sometimes V-shaped;
  • pelvis and even the fate arcuate line thickening, occurrence of at-risk symptoms;
  • hip joint space narrowing, bone hyperplasia, short bone thickening;
  • pathological lesion area fracture.

    2. Osteoclast and osteoblast activity are enhanced osteoclast can be found within the intranuclear inclusions. Hardening period, as the lack of specificity of bone tissue, but can be found mixed mosaic of old and new signs of osteoporosis and the characteristics of osteoclasts change.

    • Submitted by Health Studies on Tue, 04/07/2009 - 18:06
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