Osteitis deformation (Paget's disease)

Osteitis deformation, also called Paget's disease, is chronic bone disease featured by an unknown etiology for rheumatoid bone and joint pain, spinal and limb deformities, pathological fractures and brain, spinal cord compression. Osteitis deformation is characterized by excessive loss of control of osteoclast osteolysis caused by high speed and cause an increase in osteoblasts and bone formation are too many to generate the organizational structure of bone fragility. Bone salts and collagen was significantly higher conversion rate resulting in limited expansion of bone, osteoporosis, high incidence of pathological fracture; bone around vascular proliferation or osteosarcoma.

Osteitis deformation extensive erosion of the disease, whole body bone can be affected, most commonly in the femur, tibia, humerus, spine and pelvis. About 1% of patients with sarcoma can occur. Sarcoma happened over 40 years of age by about 1 / 5 suffering from osteitis deformation. X-ray examination showed that the early bone changes in the structure of the main damage for the absorption of the future may be cystic or honeycomb-like bone resorption was. Biochemical examination showed a normal or high serum calcium, alkaline phosphatase increased significantly, acid phosphatase concentration also slightly increased. Calcium and increased urinary excretion of hydroxyproline.