Myocarditis Causes

A variety of viruses can cause myocarditis, the most common cause is intestinal and upper respiratory tract infection. Intestinal virus for the small RNA viruses, including coxsackie, echovirus (ECHO), the polio virus as the major virus-induced myocarditis; paramyxovirus, such as influenza, parainfluenza, respiratory syncytial virus-induced myocarditis is not uncommon ; adenovirus myocarditis caused from time to time. In addition, measles, mumps, Japanese encephalitis, hepatitis, cytomegalovirus, etc. can also be caused by myocarditis. The vast majority of clinical viral myocarditis by Coxsackie virus and ECHO virus. Coxsackie B virus myocarditis group was the first human pathogens, according to their classification in order to see a maximum of two groups of 2,4, followed by 5,3,1-type; A group of various types 1,4,9,16,23 easy to violations of the baby, the occasional intrusion of adult cardiomyocytes.

1. the direct effect of the virus: the virus will be injected into the experimental blood circulation can cause myocarditis has been. In the acute stage, the patient's cardiac separable from the virus in the virus-positive fluorescent antibody test results, or in the electron microscope and found virus-like particles. Virus infection after cardiac myocyte cytolytic substances, so that cell lysis.

2. the immune response: experimental viral myocarditis in the human body 9 days after onset, myocardium can no longer find the virus, but will continue to change myocarditis; some patients with HIV infection and other minor symptoms of myocarditis is a serious performance; also some patients the symptoms of myocarditis in virus infections for some time other symptoms began to appear after the party; some cardiac patients may be found in the antigen-antibody complex. Prompted more than the existence of immune mechanisms. Primarily by cytotoxic T lymphocytes mediated by. Clinically,patient with persistent viral myocarditis, the lymphocyte transformation rate, complement C lower than normal, anti-nuclear antibody, anti-myocardial antibodies, anti-complement detection rate than normal for a high note when viral myocarditis lower immunodeficiency. The recent discovery of viral myocarditis, when the vitality of natural killer cells and interferon-α also significantly lower than normal, γ interferon is higher than normal, but also reflected the out-of-control cell-mediated immunity.

3. Other pathogenic factors: