Malignant melanoma Diagnosis

Early diagnosis for Malignant melanoma is difficult. Doctor need to ask detailed medical history, family history, clinical symptoms and detailed examination of the body and eye. In addition, scleral transillumination line, ultrasonic, FFA, CT and MRI examination with a view to making the Malignant melanoma diagnosis.

There are two classification systems can be used for the assessment of stage 1 melanoma:

1. According to the description of Breslow from the epidermal granular layer to the depth of tumor invasion as a measurement of the depth of melanoma.

2. According to Clark's classification, tumor invasion depth anatomy. In Clark's classification, Ⅰ level that is limited to epidermal melanoma; Ⅱ grade melanoma have been violations of the nipple dermis layer; Ⅲ grade melanoma has been extensively involved the nipple layer; Ⅳ grade melanoma dermal plexiform layer violations ; Ⅴ level that a violation of subcutaneous fat melanoma. Melanoma Breslow thickness and the depth of involvement (Clark level) and less increase in the prognosis.

The need for removal of pigmented lesions or biopsy criteria are: the recent increase lesion, black, bleeding or ulceration of change. However, symptoms often more than that of skin melanoma has penetrated deep. Color changes occur when the skin lesions (such as brown or black mixed with red, white or blue background), can be seen or could be reached by the irregular bulge, jagged edges or angular notch, the immediate response to biopsy lesions that can make early diagnosis. For pigmented skin damage with a mirror (an improved oil Baptist glasses) help to check the difference between melanoma and benign lesions.

Histology to determine treatment and prognosis of melanoma, primarily through a microscope observations on the histology to determine the depth of invasion. Histological grade of the need for adequate biopsy. Central nervous system and generally do not have a bed melanoma classification of these systems.

Lymphocytes reflects the depth of invasion of the patient's immune response system, and the extent of infiltration and prognosis. If only the majority of lymphocytes infiltrating superficial lesion, then a greater chance of cure, on the contrary, with the increase in the depth of infiltration, decreased chance of cure.

In addition to urine test, when urine in a large number of melanocytes and its metabolites was dark, it is helpful to diagnosis of melanoma.