Liver failure Diagnosis and Test

Liver failure is diagnosed by clinical manifestation as follow: Occur rapidly deepening jaundice In the liver based on, liver reduced at a short time, neuropsychiatric symptoms, increased transaminase enzymes or bile separation.

Some tests use to confirm diagnosis for Acute liver failure, fulminant hepatic failure:

1. Determination of prothrombin time: The check to accurately reflect the severity of the damage of one of the most valuable indicators, contribute to early diagnosis. In this study, demanding to be experienced by those in charge to accurate. Performance for coagulation zymogen was significantly prolonged time.

2. Determination of cholinesterase: the enzyme synthesis by the liver cells, the severe liver damage, serum lipase decreased cholinergic.

3. Biliary enzyme isolated phenomenon: the gradual increase in bilirubin and ALT decreased .80% of ALT present in the liver cytoplasm, when the liver cell damage, cell membrane permeability changes, ALT Ocean into the blood, early ALT can be increased, with the condition worsened, to a certain period of time the enzyme has been depleted, to its short half-life, decreased serum ALT, indicating a poor prognosis.

4. observation ratio of AST / ALT: ALT main cytoplasm in the liver, AST Most of them are in mitochondria, normal AST / ALT ratio of 0.6. When the liver cells severe damage, AST discharged from the mitochondria, the ratio that is> 1.

5. Amino acid (AA) Determination: including urine and serum amino acid analysis of the total. As a result of almost all amino acid metabolism in the liver, liver cells by the synthesis of essential proteins. When severe liver damage, AA can not be caused by the use of AA metabolism and balance disorders. First of all, a marked increase in the total AA in urine, serum in the aromatic amino acid increased support / Fang ratio from the normal 3 ~ 3.5 down to <1, indicating poor prognosis.