Liver failure

Liver failure is a liver disease that hepatocyte necrosis and severe liver dysfunction to lead to serious obstacles of metabolism, excretion, synthesis, detoxification and immune function. Common clinical manifestations is jaundice, bleeding, ascites, secondary infection, hepatic encephalopathy, renal dysfunction.

Liver parenchymal cells is the first occurrence of metabolic excretion dysfunction (hyperbilirubinemia, cholestasis of pregnancy), followed by synthetic dysfunction (reduced clotting factor synthesis, hypoproteinemia), and finally detoxifying function dysfunction occurred (anti-hormone function of living low, ammonia, amines and aromatic amino acid levels, etc.).

Liver failure occurred in a number of serious liver disease, the evil symptoms, and more adverse prognosis. Generally divided into acute liver failure and chronic liver failure.

Acute liver failure: mainly caused by viral hepatitis or drug-induced hepatitis and deterioration of other acute liver injury. The onset 2 weeks to the occurrence of hepatic encephalopathy as a prominent characteristic of those known as fulminant hepatic failure. Acute onset, rapid progress, although more current treatment, but its mortality rate is still more than 50%. Early diagnosis, early treatment can reduce mortality.

Chronic liver failure: the slow pace of the disease, the course is longer, often in some incentives under the condition exacerbated by the sudden and repeated occurrence of chronic hepatic encephalopathy.