Leukopenia and agranulocytosis Treatment
Drug therapy: lithium carbonate tablets can increase the generation of cells, but chronic bone marrow failure is void. Adult dose of 300mg, three times a day orally, after the reduction effect for the 200mg to maintain the second day 2 ~ 4 weeks. Side-effects may have tremor, stomach upset, diarrhea, itching, edema and so on, stopping to disappear. kidney disease are used with caution. adrenocorticotropic hormone or azathioprine for autoimmune neutropenia effective. Hemogram stable long-term follow-up and no infection generally do not need medication.
Recombinant human granulocyte growth factor GM-CSF and G-CSF can induce proliferation of hematopoietic stem cells into the cycle, to promote myeloid hyperplasia, differentiation and maturation, release from bone marrow to peripheral blood, and to enhance neutrophil chemotactic, phagocytic and bactericidal activity. G-CSF on the cyclical neutropenia and severe congenital agranulocytosis children better, it can accelerate chemotherapy-induced neutropenia recovery, may also be used for the prevention of chemotherapy-induced neutropenia and fever. in accordance with condition chosen 50μg/m2 subcutaneous injection once a day or 100 ~ 300μg / d subcutaneous or intravenous drip. to be picked up after leukocyte reduction or discontinuation of treatment as appropriate. CSF side effects have fever, chills, bone and other joint pain.
Anti-infective therapy: Once the patient has fever should be to do blood, urine and other relevant training, and immediately be given broad-spectrum antibiotic treatment. Pathogen to be confirmed after the switch to targeted agents. Failed to establish that pathogens such as the widely spectrum empirical antibiotic therapy must be given adequate treatment, and prevention and treatment should be noted that double infection, such as fungi, anaerobic bacteria, such as. of acute agranulocytosis who must be given strict disinfection and isolation protection, the most appropriate placement to clean up the air sterile interior and strengthen the skin and oral care to prevent cross-infection. agranulocytosis De anti-infective treatment often the key to the success of the rescue.