Leukopenia and agranulocytosis Diagnosis

Complete blood count: red blood cell and platelet count more than normal, some malignant bone marrow infiltration, accidental acute radiation accident at the same time with anemia and thrombocytopenia. White blood cell count were <4 × 109 / L, agranulocytosis, when the absolute neutrophil value <0.5 × 109 / L. lymphocytes or monocytes comparable increase. neutrophil cytoplasm often poisoning particles, such as degeneration of vacuoles. a serious infection or the left to see the nuclear blasts. should pay attention to the atypical lymphocytes and abnormal cells.

Bone marrow feature: a result of the causes vary. Early can be no significant change, but also showed a lot of young and mature granulocyte neutropenia of "sophisticated obstacle" performance, or disease was a very period of granulocyte reduced gradually recovering emergence of the various stages of PMN.

Bone marrow biopsy: marrow fibrosis, bone marrow metastatic carcinoma, lymphoma, etc. have significant value. Bone marrow examination can help the differential diagnosis of MDS.

Bone marrow culture: in vitro CFU-GM colony culture may know proliferative activity of bone marrow, bone marrow neutrophil reserves, to help identify the direct toxic effects of drugs or immune factors inhibiting neutrophil generation.

Whether or not epinephrine test for pseudo-differential assist neutropenia.

Anti-neutrophil cytoplasmic antibody determined to help identify whether autoimmune neutropenia.

Anti-nuclear antibody (ANA), rheumatoid factor (RF) titer determination, immunoglobulin determination.

Determination of serum lysozyme lysozyme prompted increased neutropenia or lack of it is due to excessive damage caused by normal or reduced lysozyme showed reduced neutrophil generation.