Leukemia Causes

The causes of leukemia are still unknown. Many factors are considered and the pathogenesis of leukemia. Viruses are probably the main factor. In addition, there are genetic factors, radiation, chemical factors such as toxins or drugs.

1) virus carrying the virus tumor virus source of tumor gene (v-onc), the majority of vertebrates (including human cells) in vivo gene has homology with the v-onc genes, said the source of tumor gene. v-onc has been integrated into the host cell genes after in vivo will enable neighboring Gene canceration happen. retroviral infection can also be the source of tumor-induced gene activation, malignant transformation to become the gene cause malignant transformation of target cells. the viral genes into the body even if it does not contain v-onc, if the change in the normal function of the gene also has may lead to leukemia.

2) genetic factors and certain genetic factors related to leukemia. leukemia patients have a family history of leukemia accounted for 8.1%, while the control group only 0.5%. consanguineous marriage crowd with acute lymphoblastic leukemia incidence rate than you might expect 30 times. have certain chromosome aberrations, fracture of the genetic disorder is often accompanied by a higher incidence of leukemia, such as Down syndrome, congenital disorder angiectatic erythema (Bloom syndrome) and Fanconi anemia. children with acute lymphoblastic 50% of leukemia patients have a special palm prints, known as the Sydney line. leukemia and HLA antigen type has some kind of contact, such as acute lymphoblastic leukemia is often accompanied by HLA-A2 and A9, etc.. show that genetic factors and the incidence of leukemia has a kinds of contact, but the majority of leukemia, the leukemia is not hereditary diseases.

3) radiation factors of ionizing radiation-induced leukemia has the role, its role and radiation dose and radiation-related sites. a larger dose (1 ~ 9Gy) or repeated low-dose effects are caused by leukemia. systemic and radiation exposure to the larger field, especially the bone marrow by radiation, which can lead to bone marrow and immune so, a few months after exposure can still be observed that the chromosome breakage and reorganization. radiotherapy can cause reversible double-strand DNA breakage, thereby enabling cells tumorigenic virus replication and discharged. radiotherapy can induce acute and chronic non-lymphocytic leukemia and chronic myeloid leukemia but not chronic lymphocytic leukemia, and bone marrow prior to the onset of a period often inhibition period, the incubation period is about 2 ~ 16 years.

4) chemical factors of benzene-induced leukemia is relatively sure. Benzene-induced acute leukemia to acute myeloid leukemia and erythroleukemia mainly. alkylating agent and cytotoxic drugs can be induced following leukemia hair than the affirmative, the majority of secondary leukemia occurred in the original lymphoid malignancies and easy malignant immune defects, as happened after the long-term alkylating agent therapy, breast cancer, ovarian cancer and lung cancer after chemotherapy is also prone to occur following the leukemia hair.