Kawasaki disease, also called muco-cuta-meous lymph node syndrome (MCLS), is acute febrile rash disease in children characterized by systemic vasculitis. Kawasaki disease is one of the factor of acquired cardiovascular disease in children, and even greater than the risk of rheumatic fever in many places.
According to pathomorphology, Kawasaki disease can be divided into four phases :
Period Ⅰ: about 1 ~ 2 weeks, which is characterized as follows:
Phase Ⅱ: About 2 to 4 weeks, which is characterized as follows:
Period Ⅲ: About 4 to 7 weeks, which is characterized as follows:
Stage Ⅳ: About seven weeks or more, vascular changes of acute inflammation are mostly gone, replaced by middle-artery thrombosis, obstruction, intimal thickening, as well as the emergence of aneurysm scar formation. On the distribution of arterial disease can be divided into:
In addition to vasculitis, the pathology also involves a variety of organs, especially in interstitial myocarditis, pericarditis and endocarditis the most significant conduction system can be affected, often at stage Ⅰ disease cause death. To the first Ⅱ, Ⅳ period common variant of ischemic heart disease, myocardial infarction can be fatal. Aneurysm rupture and there is myocarditis stage Ⅱ, Ⅲ important cause of death.
Kawasaki disease is very similar to infantile rationale polyarteritis nodosa. In addition to coronary artery or pulmonary artery aneurysm and thrombosis, the aorta and pulmonary artery or conduit, such as changes in both intima. Fluorescent antibody examination showed heart, spleen, lymph nodes of the arterial wall are composed of immunoglobulin IgG. Cervical lymph node and skin absorption can occur vasculitis, with necrosis of small vessels fiber. There is a high degree of shrinkage of the thymus, heart weight increased, the expansion of ventricular hypertrophy, liver steatosis and mild hyperemia and follicular lymph nodes increased. However, there was no significant glomerular lesions.