Early symptoms of hypermagnesemia include the loss of appetite, nausea, vomiting, skin flushing, headache, dizziness and so on. When the serum magnesium concentration is 2 ~ 4mmoL / L, it will be a serious symptom.
1. Impact on nerve - muscle system: increased serum magnesium ions inhibit nerve - muscle joints and central nervous system release acetylcholine, it manifested as myasthenia gravis and central inhibition of respiratory status. Serum magnesium concentration> 4.8mmol / L, the occurrence of myasthenia gravis, muscular limbs, flaccid paralysis, respiratory muscle affected, they can happen respiratory failure, respiratory arrest. Serum magnesium concentrations> 6mmol / L may inhibit major hub, such as drowsiness, stupor, coma and so on.
2. Impact on the heart system: self-discipline is mainly expressed in cells, showing sinus bradycardia, various organizations of the conduction block. Normal cells because of high to lower the self-discipline, low self-excited cells, a variety of arrhythmias can occur.
3. On vascular effects: high blood magnesium preganglionic sympathetic nerve fibers can inhibit the release of acetylcholine, the corresponding reduction of noradrenaline release; also inhibit parasympathetic acetylcholine release, performance for the vascular smooth muscle relaxation, skin flushing, blood pressure dropped.
4. Impact on the digestive system: High blood magnesium inhibit neurotransmitter release independently, and direct inhibition of gastrointestinal smooth muscle, there is an indication of abdominal distension in patients with constipation, nausea, vomiting and so on.
5. Impact on the respiratory system: severe high blood magnesium can reduce the excitability of respiratory center and respiratory muscle paralysis, leading to respiratory arrest.