Giant Cell Tumor of bone

Giant cell tumor of bone, also called osteoclastoma, is a common one of the primary bone tumor. Giant cell tumor of bone is osteolytic tumors that come from bone marrow stromal cell differentiation with monocytes as the main component. Giant cell tumor of bone is a benign bone lesion, usually single and a local invasive. Giant cell tumor of bone is a potentially malignant tumor, and some giant cell tumor after surgery can be relatively simple to obtain long-term control, while others are giant cell tumor metastasis may be disseminated. For specific patients with giant cell tumor, through the analysis of its clinical, imaging and histology to determine the prognosis of the performance is very difficult, and is very determined. Jaffe in 1940 since the first description of the tumor has been deepening its understanding: The tumor has a strong erosion of the bone destruction of a great solution, but very little reactive new bone formation and self-healing tendencies; cortical bone can be formed through a larger mass of soft tissue; curettage method using the usual very high relapse rate; a small number of cases of malignant transformation may be partial or lung metastasis.

Giant cell tumor of bone is most commonly in the 20 ~ 40 years old, the peak age for another 55 to 65 years old, less than 10% of giant cell tumor of bone occurred in immature bone, no gender differences in incidence. Giant cell tumor of bone of the primary site occurred in almost all the epiphysis, with the gradual expansion of lesions and metaphyseal invasion. Giant cell tumor of long bone and more violations in order to distal femur and proximal tibia has the most. Other multi-site followed by distal radius fracture, fibula and the proximal femoral head, such as the proximal humerus. About 20% of giant cell tumor of bone occurred in the hand, spine and pelvis, and other non-long bone.