Galactosemia Causes

Galactosemia causes is lack of Galactose kinase, UDP-galactose isomerase and 1 - phosphate acid UDP galactose transferase. Galactose not cause organ toxicity by itself, but its metabolites such as 1 - phosphate galactose and galactose alcohol, and various components of selective organ damage, such as galactose-induced cataracts alcohol is the main material, and on liver and kidney toxicity days.

A few weeks after birth, liver disease, including cholestasis, extensive fatty degeneration, no inflammatory cell infiltration, false biliary ducts form, false gland hyperplasia, liver cell damage, false gland hyperplasia is characterized by galactosemia without specificity. With the emergence of disease progression desmoplastic small. hyperplasia of fibrous tissue around the portal began in the future, constitute an extension to the portal area bridge-like connection, after the formation of regeneration nodules, in the course of its changes in liver cirrhosis and alcoholic liver cirrhosis Similarly, in the course of the entire lesion has no significant infiltration of inflammatory cells.

In addition to liver lesions, the renal cortex and medulla tubular junction expansion, splenomegaly of portal hypertension can be caused by brain lesions minor.