Colorectal Lymphoma Overview:
Primary Colorectal Lymphoma is malignant lymphoma that primary in intestinal node. Secondary Colorectal Lymphoma is the other parts of the malignant lymphoma in the course of the disease involving the gastrointestinal tract. From onset occult primary, early lack of specificity, often due to delayed treatment and poor prognosis. Multiple rich in lymphoid tissue of the ileum and cecum, followed by distribution of right colon were limitations can, but generally involved a wide range of more cancer.
The exact cause of colorectal malignant lymphoma is unknown, may be related to radiation, chemical carcinogens, toxins.
Colorectal Malignant Lymphoma Symptoms:
1. Diffuse: to infiltration is characterized by diffuse thickening of the intestinal wall hard, can see the loss of normal luster with intestine lesions, mesocaval narrow peristalsis disappeared after the injection of gas can not expand mesocaval. Mucosal thickening can be seen side of brain may fold back to form, but also showed diffuse nodular changes in the surface erosion or superficial ulceration, similar to invasive carcinoma, but involving a wide range.
2. Polyp type: mass base was wide, smooth surface was nodular or polypoid mass, often misdiagnosed as benign polyps or polyp-like carcinoma. The surface of tumor large ulcers and bleeding can occur and may cause intestinal stricture. Can also be a multiple of almost equal size of polyps in the hemisphere, similar to benign lymphoid polyposis. Smooth surface, white color. However, because of infiltration of local thickening of the colon and a half fold bag disappeared, local stiffness, creep disappear.
3. Ulcerative type: malignant lymphoma can be characterized by a malignant ulcer, but some patients may also be manifested as changes in benign ulcers: superficial ulcer flat, white surface coating, such as flat embankment weeks. In addition, there are a parenteral mass type, the causes of tumor growth within the intestine caused by outside, so that it can be oppressive mesocaval narrow, but the normal mucosal surface.
Colorectal Malignant Lymphoma Diagnosis:
Fiber colonoscopy is main method of diagnosis for malignant lymphoma of the large intestine. Endoscopic high positive rate is of 50% to 80%, it is noteworthy that even though at times under a high degree of suspicion, including malignant lesions, but biopsy can always find inflammatory cell infiltration, no cancer. This is because the type of malignant lymphoma, although the histological features of certain organizations such as the different types of cells and lymphocytes, such as pathological karyokinesis, structure damage, but too often based on shallow, small tissue organization clamp such as at the time of extrusion can not be confirmed. Therefore this disease is different from colon cancer based on biopsy, in addition to mucous membrane material, the folder organization from submucosal necessary. Once the results of endoscopy and pathology results not to be alert on several occasions the possibility of this disease.
Colorectal Lymphoma Treatment:
Treatment for Primary Colorectal Lymphoma is comprehensive treatment that combination of surgery, radiotherapy and chemotherapy. Treatment Principles:
1. once confirmed diagnosis, the use of chemotherapy, surgery (for further disease stage, radical resection of tumor or palliative tumor resection, residual lesions folder marked silver, etc.), postoperative chemotherapy, radiotherapy (or not), the maintenance chemotherapy.
2. no preoperative diagnosis, and the first radical or palliative resection of tumor in order to obtain the exact pathological classification and clinical staging, etc., and then proceed to post-operative chemotherapy, radiotherapy, maintain chemotherapy.