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Colorectal Cancer spread, metastasis and growth

Colorectal Cancer spread and metastasis:

1, a direct invasion: the spread of colorectal cancer directly through the intestinal wall within the Department of lymphatic vessels develop in the direction of the vertical longitudinal axis, that is, along the intestinal circumference and to the deep infiltration, the long axis parallel to the proliferation of intestinal less, therefore, rarely go beyond the tumor, the lower edge than 2 ~ 3cm. It was observed 236 cases of pathological specimens of colon cancer, bowel wall by tumor infiltration beyond the upper and lower than 4cm only 0.5%. To break the direct spread of invasive serosal layer and the adjacent organs such as liver, gall bladder, bladder, uterus, vagina and so on. Or disseminated intra-abdominal implanted.

2, cultivation spread: a common way of planting the following three kinds of situation.

  • intraperitoneal cultivation: outside the cancer cell invasion to the serosa can be detached from the surface of intra-abdominal organs, causing abdominal disseminata cultivation. Peritoneal metastasis is a complex biological process, a good site there is greater omentum, mesentery, bladder rectum Au, Au, such as the uterus rectum to pelvic fossa Douglas near the more common; can when vaginal palpation and induration, but also can be widely planted in the abdominal cavity, the formation of cancerous peritonitis.
  • mesocaval cultivation: mesocaval colorectal cancer in the vicinity of the cancer cells often detached attachment in mucosal integrity, the growth of cancer cells do not grow, but if there is intestinal damage, breakage may occur in cultivation, It may also be the focus of colorectal cancer are often one of the reasons frequently-occurring disease.
  • cultivation of medical sources: multi-operation process, the cultivation in anastomotic and abdominal incision. Operation should take precautionary measures to be avoided.

    3, lymph node metastasis: large intestine carcinoma in the mucosa without lymph node metastasis may be, but as lesions infiltrating to the muscularis mucosa below, there is the possibility of lymph node metastasis. Lymph node metastasis and more erosion of the intestinal wall after the transfer, operation of regional lymph node metastasis, there were up to 30% ~ 68%. Transfer channels are generally transferred to the first artery and the colon along the edge of the lymph nodes in parallel, and then along the mesenteric vascular lesions intestine to start the Department of vascularized lymph nodes, such a first parallel direction along the tube line, and then along the blood vessels to the central mesangial means of lymph node metastasis is characteristic of colon cancer. A few cases, can also jump the queue and the transfer was by leaps and bounds; in particular, lymph node drainage areas have blocked the transfer and after transfer can occur retrograde into the proximal or distal lesions of the lymph nodes. The existing transfer of mesenteric lymph nodes from the proximal colon or distal colon 7cm Department there is a lymph node metastasis rate of 10 percent. But cancer is not, the lymphatic drainage of rectum immediately after the rectal blood vessels along the course, a reversal of the phenomenon of metastasis is extremely rare.

    4, blood metastasis: more than a small vein in the violations along to the intrahepatic portal vein. The time of diagnosis of colorectal cancer, 10% ~ 15% of cases transferred to the liver, the autopsy and 2 / 3 transfer to the liver, can also paravertebral venous plexus by Baston and first lung metastasis, and other organs such as bone, chest , kidney, ovarian, skin transfer may occur. Obstruction or surgery, such as extrusion forming, the result from the transfer of blood. 6cm from the anal margin of rectal cancer following the transfer of the highest rates of blood, up to 40% ~ 50%; followed by the upper rectum, about 20%. Colon cancer metastasis rate of less than 10%.

    Colorectal cancer multi-center growth:
    The vast majority of colorectal cancer for the individual, a small number of cases at the same time or one after another for more than one occurrence of the cancer, the tendency after multiple skin and breast. The number of cancer can be as much as 2 to 5, the vast majority of multi-center cancer (82%) for the two foci. Multi-center cancer diagnostic criteria are:

  • foci scattered between normal bowel wall, it was reported that the 6 ~ 10cm apart, 35%, far less than 2cm of 16%;
  • close to one another except for the cancer to be broadcast submucosal bulk transfer and hand-surgery relapse. Metachronous multiple cancer, there is a difference in time between 2 to 6 years, but can also occur after 20 years in the case, must be differentiated from recurrence of previous surgery.
    • Submitted by Health Studies on Fri, 04/17/2009 - 13:10
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