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Colorectal Cancer

Colorectal Cancer (Colorectal Carcinoma) Overview:

Colorectal Cancer (Colorectal Carcinoma) is malignant lesions in large intestinal mucosa as a result of cancerogenic substance such as the environment or genetic factors, poor prognosis, high mortality, is one of common malignant tumors. Colorectal malignancies originated in the mucosal epithelium or submucosal mesenchymal tissue. Which took place from malignant epithelial collectively referred to as colorectal cancer, for the most common gastrointestinal malignancy, second only to stomach cancer, esophageal cancer. Men the incidence of colorectal cancer was significantly higher than women, and about 1.6:1.

Type of Colorectal Cancer (Colorectal Carcinoma):

1. The general colorectal cancer type:

1) Early colorectal cancer: colorectal cancer confined to submucosa layer and said early colorectal cancer, no lymph node metastasis in general, but the cancer invasion to submucosa, some 5% ~ 10% localized cases of lymph node metastasis, in accordance with the naked eye Observation of early colorectal cancer is divided into three stage.

  • polyps protruded type: there are local uplift the appearance of the mucosa. This type of cancer for the mucosa.
  • flat protruded type: mucosa slightly thick, near-normal, surface processes, or minor uplift, it seems like coins.
  • flat protrude with ulcer; such as small discoid, edge swell and Depression Center. Cancer in the submucosa only.

    2) advanced colorectal cancer: means the cancer tissue in the mucous layer the following violations, up from serosal layer. Naked eye is divided into three stage.

  • mass type: The main growth of the cavity, were spherical or hemispherical, the performance of a majority of small ulcers, bleeding easily. This type of infiltration of small, late occurrence of lymph node metastasis, prognosis was good.
  • ulcer-type: the beginning of mass for the flat, after the central necrosis, the formation of large ulcers, butterfly edge eversion was the face of easy bleeding, infection.
  • infiltrating type: cancer tissue growth along the intestinal wall invasion, with a clear response of fibrous tissue, causing stenosis and intestinal obstruction, lymph node metastasis in early, poor prognosis.

    2. Colorectal cancer histologic types:
    Generally divided into adenocarcinoma, mucinous carcinoma and undifferentiated carcinoma.

    1) adenocarcinoma: cancer cells with positive tubular-like or alveolar. According to their degree of differentiation, according to Broder divided into Ⅰ ~ Ⅳ level, that is, low-grade (well differentiated), malignant secondary (differentiated), high grade (poorly differentiated), and undifferentiated carcinoma. See more of this type.
    2) mucinous carcinoma: cancer cells secrete more mucus, mucus in the extracellular matrix or concentrated in the cell nuclear marginalized, and more from mucus cells and poor prognosis.
    3) undifferentiated carcinoma: small cells, were round or irregular in shape, showing irregular arrangement of the sheet, clear invasive, easy-intrusion of small blood vessels and lymphatic vessels, and poor prognosis.

    • Submitted by Health Studies on Fri, 04/17/2009 - 12:56
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