Chronic myelogenous, lymphoblastic leukemia Causes

What're the cause of Chronic myelogenous leukemia (CML)?
Patients with chronic myelogenous leukemia have the "Philadelphia chromosome" (Ph chromosome). Each have nuclear cells have chromosomes exist, Ph chromosome No. 22 as a result caused by chromosome breakage. Chronic myelogenous leukemia patients No. 9 chromosome and chromosome No. 22 has a section on cross-exchange, chromosome No. 9 of the fracture and the "ABL" gene related to chromosome No. 22 of the rupture and "BCR" gene-related. When the period of receiving the ninth section of chromosome the end of the 22nd chromosome, the formation of BCR-ABL oncogene. BCR-ABL oncogene, a protein synthesis can be controlled, cause chronic myelogenous leukemia.

What're the cause of Chronic lymphoblastic leukemia (CLL)?
Chronic lymphoblastic leukemia has yet to know the causes, genetic factors may play a role, some patients have chronic lymphocytic leukemia karyotype, the abnormal quantity and structure, of which 12 to 14 found abnormal chromosome, chromosome 12 in three body the most. B-cell chronic lymphocytic leukemia chromosomal translocation (11; 14), the chromosome 11 genes on the original tumor bCL-1 (B-cell lymphoma / leukemia 1 1) translocation to chromosome 14 contains a re - chain gene of fracture point, resulting in abnormal protein, may be B cell growth factor. the majority of chronic lymphocytic leukemia B-cell, T cell rare.