Chronic myelogenous leukemia (CML) Symptoms

Symptoms of CML in infancy is different to CML in adult.

1. juvenile chronic mydogenous leukemia (JCML), this type appear in children mostly under the age of 5, especially in the age of 2 infants and young children mostly. Male incidence than women. May happen in the family of neural fibroids, reproductive or urinary tract malformation of children with mental retardation.

Onset may be acute or slow, often the chief respiratory symptoms. Mostly facial rash or eczema-like rash, or even purulent rash, the skin can also be found coffee spots, skin symptoms may be seen in the leukemic cell infiltration in a few months ago. Lymph node swelling large, even purulent. progressive hepatosplenomegaly. because of thrombocytopenia is not rare and secondary hemorrhage.

JCML originated in hematopoietic stem cells can be many, it could result in obstacles to erythroid hyperplasia, abnormal platelet count and volume, and abnormal lymphocyte function. With adult different tablets of dysplasia, mainly in single-system, mainly cultivate stem cells in vitro the formation of CFU-GM . many normal chromosome examination, the individual can be seen -7, +8 (trisomy 8) or +21 (trisomy 21).

Peripheral blood leukocytes as increased platelet reduction and moderate anemia. Leukocytes moderately increased at many 100 × 109 / L following. Immature myeloid and nucleated red blood cells may appear in the peripheral blood, and has mononucleosis. Leucocyte alkaline phosphatase decreased, even normal. lysozyme in serum and urine increased. HbF increased. myeloma tablets: red for the 3 ~ 5:1. granulocyte and monocyte hyperplasia strong line shows abnormal erythroid hyperplasia. myeloid original at below 20%. megakaryocyte reduction. in vitro cell culture of bone marrow mononuclear cells in the main. JCML often cause fever, hepatosplenomegaly, moderate anemia, leukocytosis, and infection to be caused by differential leukemoid reaction. It should also be with infectious mononucleosis identification.

2. Adult chronic myelogenous leukemia (ACML) at the age of onset over the age of 5 to 10 ~ 14 years old See more rarely found in children under the age of 3. Men and women is not very different. Because many are hematopoietic malignant proliferation of stem cells, the granulocyte, erythroid, megakaryocyte and so many department involvement, BC lymphoblastic leukemia can be changed. about 85% of children with Ph1 chromosome exist (ie, t (9:22)). of Ph1 chromosome negative, using molecular biology techniques have bcr restructuring can be divided into (phbcr + CML) and bcr recombinant (PH-bcr-cml) two subtypes. PH1 former clinical symptoms and similar chromosome-positive, which clinical symptoms not typical.

Slow onset, beginning when symptoms are relatively light, and showed weakness, weight loss, bone and joint pain. Visible signs of splenomegaly, hepatomegaly, mild swelling of lymph nodes, such as papilledema. There is very little bleeding.

Mainly as peripheral blood leukocytosis, 80% at 100 × 109 / L or more. Hemoglobin at 80g / L or so. Thrombocythemia. Classification can be seen an increase in granulocyte, including the eosinophil, basophil number. Myeloid original number was not obvious, in late David and sophisticated cell-based tablets. leukocyte alkaline phosphatase to reduce. HbF is not elevated. does not increase serum immunoglobulin. myelodysplastic active to granulocyte hyperplasia mainly original PMN <10%, many for the Middle and Late promyelocyte cells and rod-shaped cells. tablets: red for the 10 ~ 50:1. myelofibrosis can be seen in some patients. megakaryocyte in bone marrow increased to mature mainly megakaryocyte. lysozyme in serum and urine are not increased However, protein VitB12 and increased delivery VitB12. cultivate bone marrow colony number were charged with Cong.