Chronic myelogenous leukemia (CML) Diagnosis

1. Complete Blood Count: high white blood cell count at 100 × 109 / L or more blood film were mostly rod-shaped nucleus and a neutral late promyelocyte, and the remaining leaf for the sub-nuclear, in the promyelocyte, promyelocytic leukemia cells and a few original tablets. eosinophilic and basophils also increased. Early mild reduction in hemoglobin and red blood cells, platelets and normal or increased, the late reduction of red blood cells and platelets. Hemogram areas in and have to identify with leukemoid reaction.

2. Bone marrow Biopsy: Bone marrow hyperplasia was evident from the extremely active, peripheral blood cell classification and is similar to bone marrow film, it can be seen that the period of granulocyte, which in late promyelocyte-based, the original early neutrophil promyelocyte increase above normal , but generally not more than 5% ~ 10%, eosinophils, and (or) an increase in basophils, the relative reduction of erythroid, granulocyte: red for about 10 ~ 50:1, young red blood cell and megakaryocyte often increased early and late reduction .90% of patients with mature neutrophil alkaline phosphatase activity decreased significantly.

3. Chromosome: Ph 'chromosome in more than 90% of CML patients. Ph' chromosome CML be considered multipotent stem cells of the tumor markers, a small number of CML patients with Ph 'chromosome negative, according to the availability of Ph' chromosome can be CML for Ph 'positive and Ph' negative two categories, the former is superior to the latter prognosis.

4. Blood biochemical: serum vitamin B12 and vitamin B12 concentrations were significantly increased binding capacity characteristic of this disease, the rate of increase directly proportional to the degree and leukocytosis. The reason is that the substantial increase in normal and leukemia cells of an excessive number of tablets vitamin B12 transport protein I. cobalt to the serum uric acid concentration can be increased, particularly in the chemotherapy.