Chronic myelogenous leukemia (CML)
Chronic myelogenous leukemia (chronic granulocytic leukemia, CML) is a clonal hematopoietic stem cell proliferative disease, characterized by myeloid hyperplasia in bone marrow, peripheral blood leukocytosis and splenomegaly. More than 90% of patients with characteristics of bone marrow cells in the presence of Philadelphia chromosome (Ph chromosome) and (or) BCR / ABL fusion gene.
Its typical clinical course including the chronic phase (CP), accelerated phase (AP) and blast phase / crisis (BP / BC). From the chronic phase to accelerated phase or blast crisis phase CML are the natural evolution of disease development. CML and other myeloproliferative disorders, a significant difference is that the probability of occurrence of very high BC and BP are the terminal stage of CML, in addition to disease control or other non-patients died of causes of this disease, almost all will progress CML to BP.
Chronic myeloid leukemia often remain stable in a few years, and finally into a higher degree of malignancy of the disease in the patients aged between 30 to 40-year-old mostly a rare age of 20.