Chronic lymphoblastic leukemia (CLL) Symptoms

B-cell Chronic lymphoblastic leukemia is slow onset, early often asymptomatic, may be at physical examination or routine inspection found occasionally, while others due to lymph nodes or hepatosplenomegaly was found.

Lymph nodes is the most common (70%) symptoms, can be generalized, mild to moderate swell, even obvious swelling, no tenderness, there is rubber on the sense of touch, and skin does not adhesion, is commonly found in neck, armpits and groin, etc.. tonsils, lacrimal gland, salivary gland tired in time, can produce Mikulicz syndrome.

Hepatosplenomegaly, splenomegaly is the common (40%) symptoms, mild to moderate swelling, pelvic up late, can occur even splenic infarction or splenic rupture. Hepatomegaly (10%) than the degree of spleen, When swollen with obvious damage to liver function, advanced cases often prompt.

The performance of other organs 50% of patients with infiltrating the skin there is the performance of slower tablets found, such as specific nodules, erythroderma, also have non-specific disorders such as itching. Stomach and small intestine infiltrating common visible satisfied minus, abdominal distension, dyspepsia, and feces, diarrhea and so on. have diffuse pulmonary infiltration of the main nodule, miliary infiltration (40%) and pleural effusion (15%). Hydrothorax often bloody, may also happen due to lymphatic obstruction chylous pleural effusion. there is a common disease of bone and demineralized bone thinning (5%), osteolytic rare. 60% of pathological examination in patients with bilateral renal infiltration of leukemia, it is generally mild disease, approximately 20% of patients have proteinuria and microscopic hematuria. nervous system lesions have punctate brain invasion, and even the formation of nodular brain tumor, meningitis may also occur, the first seven pairs of cranial nerves, hypothalamus, pituitary and peripheral neuropathy, increased intracranial pressure can be.

The performance of immune deficiency: band or a higher incidence of herpes simplex. Suppurative patients have easy such as pneumonia and other infections. There is also associated with a second malignant tumor, especially in skin and colon tumor. At the same time, with diffuse hair cells lymphoma, and known as Richter syndrome, the occurrence rate of about 3.3%. The hair may also be associated with, such as rheumatoid arthritis and myasthenia gravis.

T-cell Chronic lymphoblastic leukemia rapid onset of symptoms, hepatosplenomegaly, moderate number of lymphocytes are often violations of the central nervous system, gonads and the deep dermis, bad reaction to treatment, survival time is short.

Chronic lymphocytic leukemia is a disease of middle-aged and older people, about 90% of patients aged over 50 years old, the average age is 65. Are occasionally found in many patients lymphocytosis. Usually the earliest symptoms are weakness, fatigue , shortness of breath when physically active. If it is found that cervical lymph node enlargement in particular, should be first of all caused by the patient's attention, the late train piles, diameter up to 2 ~ 3cm, no tenderness, quality hardware, removable. mesenteric or peritoneal lymph nodes can cause symptoms of abdominal or urinary system. mild to moderate swelling of the spleen, the liver can also be enlarged. later appeared anorexia, weight loss, low-grade fever, night sweats, anemia and other symptoms. about 10% or more of patients can happen autoimmune hemolytic anemia, anemia often more serious at this time, there may be jaundice. late may have skin purpura and bleeding tendency, vulnerability, especially respiratory infections. This is normal to reduce the emergence of immunoglobulin, which may be the death of the direct reasons.