Chronic lymphoblastic leukemia (CLL)

Chronic lymphoblastic leukemia (CLL) is blood diseases that monoclonal expansion of small lymphocytes, infiltrating bone marrow, blood, lymph nodes and other organs, eventually leading to failure of normal hematopoietic. On this type of cell morphology similar to mature lymphocytes, but is an immature immune study, dysfunction of the cell. The vast majority of CLL for the B cell, T cell were less.

With molecular biology, cytogenetics progress of the genetics of CLL variant with a new breakthrough and it was found that this genetic variant and clinical symptoms, the prognosis is closely related to. For example, in the late or slow the progress of leaching period, often 12 trisomy and (+12), and in particular oncogene P53 are abnormal, it and the age, sex, drugs had nothing to do. At the prognosis aspects: complex chromosome variability and significantly related to poor prognosis, and its high grade, while the normal chromosome or a single chromosome abnormality better prognosis.