Chronic leukemia Treatment

1. The treatment of the principle: For the treatment of chronic leukemia do not have to rush, white blood cell count at 100 × 109 / L without immediately following the treatment of patients, mainly because the cycle of myeloid maturation, and its small cell size than the original and has a better deformation capacity, white blood cell count at 200 × 109 / L or more aggressive treatment measures to be taken. At present, the use of cytotoxic drugs for chemotherapy. For those who leukocyte proliferation and the extreme symptoms, if priapism, respiratory distress, blurred vision, abnormal psychology, etc., should be removed during the surgery interleukin acute on the basis of combined treatment with inhibitors of bone marrow.

2. Chemical treatment: effective drug has BUS (Maryland), HU (hydroxyurea), CTX, CLB ,6-MP (6 - mercaptopurine), MMC (mitomycin C). One of the preferred drug for a BUS, followed by for HU.BUS is the most effective drug, remission rate at 95%, drugs are easy to take advantage of this end. Usage 2mg daily for 3 times to have been used to interleukin 14 × 109 / L or disable the following intermittent administration. general rules of use are 1 ~ 2 weeks to improve symptoms, 4 to 6 weeks a marked improvement. When leukocytes to 10 × 109 / L, the reduction to 1 ~ 2mg / d, has been maintained for 2 ~ 3 months . discontinuation after leukocyte such as fluctuations in the 10 ~ 50 × 109 / L, the low dose may be considered to maintain more than one year. leukocytes reduced to 5 ~ 10 × 109 / L platelets at 100 × 109 / L the following, or have chronic myeloid CML should be inclined to stop. myleran main toxicity was myelosuppression, especially thrombocytopenia. Although the dosage of individual patients would not appear to reduce the whole blood cells, slower Recovery. a long time to take the drug can cause pulmonary fibrosis, skin pigmentation. similar adrenocortical dysfunction of chronic symptoms, or stop by the lack of semen.

3. Radiotherapy treatment: deep x-ray, with deep x-ray of the systemic and local infiltration of the liver and spleen, as well as site exposure. Splenic irradiation dose for the start 50cGy, after a day or the next day 100 ~ 200cGy. Leukocytes dropped to 20 × 109 / L stop. to the poor effect of chemotherapy or radiotherapy can relapse, it is reported that the efficacy of not less than the BUS. nuclides 32P treatment, only for the BUS and the effect of splenic irradiation poor .32 P dose was based on leukocyte increasing degree, if the WBC> 50 × 109 / L, 32P of the start dose of 1 ~ 2.5mCi, intravenous .2 weeks followed by 1 ~ 1.5mCi, after every two weeks to the same dose one time, to be WBC to 20 × 109 / L pm. at ease during the period, each 1 to 3 months to observe one time, when the WBC> 25 × l09 / L, they can give 1 ~ 1.5mCi.

4. Splenectomy: the spleen in chronic leukemia are probably the first part of CML, may delay the removal of the spleen and the extension of patients with CML survival. Resection of the spleen of the surgical indications: ① were diagnosed with CML; ② the favorable response to chemotherapy; ③ 65 years of age major surgery and no contraindication were. blast crisis CML are contraindication surgery.

5. Bone marrow transplantation: the age of 45 to 50-year-old patients in the chronic phase to the same family of HLA allogeneic bone marrow for transplant. Transplant success, the general can be a long-term survival or cure.