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Chondromalacia Patella Causes

Causes of Chondromalacia Patella is unknown, it is probably caused by follow:

1. Bio-mechanical factors

  • the trauma: in the pathogenic factors of chondromalacia patella in Chondromalacia think trauma is an important cause of disease. Direct trauma, indirect trauma and repeated the role of a variety of articular cartilage over the physiological range of physical stress, resulting in articular cartilage of "shell structure" and "arch" damage, cartilage cells lose their protection and necrosis, cartilage matrix synthesis reduced cause of damage to articular cartilage.
  • patellar instability: unstable patella patellar mainly refers to high, low patella, patellar tilt, patellar subluxation or dislocation. Patellar instability can cause increased pressure on the patellar articular surface, the distribution of abnormal, causing cartilage damage.

    2. Biochemical factors

  • auto-immune:
    Articular cartilage surface to prevent anti-collagen antibodies into the deep tissue and cartilage has the protection of their role. Articular cartilage damage in the synovial fluid of patients found to have anti-type Ⅱ collagen antibodies, immunofluorescence method in patients with chondromalacia patella examination of lesion specimens and found that damage to cartilage tissue and remnants of the region on the cartilage cells have immunoglobulin IgG, IgA, IgM and complement C3 attachment.
  • cartilage nutrition disorders:
    A variety of injury factors (in particular, mechanical stimulation) to enable the secretion of synovial fluid and its components (such as enzyme activity, a variety of nutrient content, the osmotic pressure of synovial fluid, etc.) anomalies happen, the impact of normal patellar cartilage nutrition and physiological and biochemical processes, to the pathogenesis of cartilage degeneration. Because of epiphyseal articular cartilage in the epiphyseal cartilage complex of the viability of cartilage vessels are highly dependent on the blood supply, the shortage of blood for chondromalacia patella is one of the causes.
  • cartilage dissolution:
    Synovial changes in osmotic pressure after the injury, the plasma into the synovial fluid increased the enzyme activity increased, and then dissolved cartilage.

    Therefore, collagenase reduce contact stress at the side of the patella in Chondromalacia play an important role in the process. At present, most scholars are inclined to think that chondromalacia patella is a wide range of factors, a variety of factors patellofemoral joint stress-induced changes in external factors, autoimmune response, cartilage nutrition obstacle is chondromalacia patella of the internal happen.

    • Submitted by Health Studies on Wed, 04/08/2009 - 15:42
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