Barrett syndrome, also called chronic peptic ulcer and esophagitis syndrome, is condition that esophageal gastric mucosa was replaced by columnar epithelium. General Barrett syndrome is congenital, but often secondary from reflux esophagitis, often occur Esophagitis and ulcer base on reflux of stomach and esophagus.
Barrett syndrome Causes and Pathological changes: the non-acid-resistant squamous cell damage, acid regeneration of the columnar epithelium and gradually spread upward lower esophageal involvement. Fresh ulcers penetrate the wall, so that fibrosis and mediastinal lymphadenitis occurred, if vascular damage is caused by bleeding, mediastinal and pleural lesions can be purulent. Microscopy mucosal lining of columnar epithelium with atypical hyperplasia and abnormal.
Barrett syndrome Symptoms: the disease was particularly prevalent in middle-aged or elderly. When eat the cold and hot food, especially acidic food, or take lying, occur symptoms include lower recurrent retrosternal pain and burning sensation, pain can be radiation to the neck, scapular or arm. Late may have difficulty swallowing, vomiting, hematemesis, black feces, etc.. In addition, can be complicated by perforation or bleeding ulcers.
Barrett syndrome Diagnosis and tests: Often diagnosed by X-ray and Esophageal endoscopic examination.
1.X-ray examination showed esophageal wall can be seen in isolation of crater-like ulcers, remote from the crater or the disappearance of the typical fold of the fold, the top of spastic disease, and stenosis due to edema.
2. Esophageal endoscopic examination showed ulcer crater-like lesions, mucosal folds due to clearance, inflammatory edema, bleeding, white spot. Exfoliated cells to check non-malignant cells.
Barrett syndrome Treatment: often need surgical treatment. Drug therapy can be applied mucosal protective agent sucralfate, given H2-receptor blocker or proton pump inhibitors. Prepulsid prokinetic drug to prevent reflux of a certain effect, each time 5 ~ 10mg, 3 times a day.