Amebic dysentery Pathogen

The Pathogen of amoeba is the interaction between parasites and hosts, and there are many factors which affect the complexity of the process. Entamoeba histolytica invasion force of mainly manifested in the solubility of the host tissue damage. Entamoeba has proved to have a wide range of proteolytic enzyme activity, but has not been able to successfully separated. Experimental proof of life on the trophozoites of the destruction of the role of host cell lysis have contact lysis of the characteristics of acid phosphatase amebic dysentery cells for chemical analysis, indicating that the active substances present in the plasma membrane and food vesicle membrane, and thus the membrane bound enzyme arguments. Also from amoebic dysentery in vivo hydrolysis extraction gelatin, casein, fibrin, hemoglobin and other objects of the enzyme. Experiment with the electron microscope showed that not only engulfed erythrocyte trophozoites, but also interleukin tag. Parasite Entamoeba Lushbaugh also soluble extract isolated from an intestinal toxicity with cytotoxic properties, in the pathogenesis of amoebic dysentery are also lifting effect.

Entamoeba strains of insect problems, modern research shows that the virulence of Entamoeba are hereditary, but the intensity of virulence varies with the strain. Amoebic dysentery a high incidence of insect-infected trees in tropical areas, because of the long-term parasite to adapt to the organization, it has a strong toxicity; and boreal, temperate regions weaker strain virulence, with more insects are. However, the virulence of strains is not fixed, but can increase the passage of animals, may also after long-term in vitro culture and weakened, but if by the inoculation of animals and so to increase virulence. The emergence of virulence in two-and mesocaval bacteria associated with the relationship with each other. Has been to their own experiments that simply can not eat clean dysentery amoeba cysts, only with insects, and then swallow in patients with intestinal cells dysentery occurred. This synergy led to disease is likely due to the proliferation of bacteria amoeba can provide physical and chemical conditions and activities, for example, of an appropriate redox potential and hydrogen ion concentration and so on, at the same time weaken the host bacteria may also be full or partial resistance power, and even direct damage of intestinal mucosa, in order to provide opportunities for invasive Entamoeba.

The immune status of the host whether the amoebic invasion of the important role of organizations, amoebic dysentery must break through the host's defense barrier to invasive breeding organizations, clinical and experimental data show that due to malnutrition, infections, intestinal disorders, mucous membrane damage Host factors such as systemic or local immune dysfunction, are conducive to amebic invasion of the organization. Nutrition standards in low-population or experimental animals, the incidence of amoeba and pathological indices were significantly higher than those who balanced diet, and not for drug control; typhoid, schistosomiasis, tuberculosis and other gastro-intestinal or systemic infection prone patients suffering from amoebiasis, difficult to cure Amebic dysentery.

Entamoeba histolytica trophozoites large, Amebic dysentery (Intestinal amoebiasis) is caused by amoeba invasive the intestinal wall, a common site in the cecum, followed by the rectum, sigmoid colon and appendix, transverse colon and descending colon uncommon, sometimes involving all or part of the large intestine ileum.