Allergic vasculitis Symptoms
The main symptoms of Allergic vasculitis is nodular erythema occurred in lower limbs, and tenderness can also be associated with purpura, purpuric papules, wind groups, blister dome lesions. Pathological manifestations of the skin vessel walls have inflammatory cell infiltration, mainly polynuclear leukocytes and fibrin deposition, perivascular infiltration of many leukocytes, nuclear dust and red blood cells associated with exudation.
The Allergic vasculitis types and its symptoms:
1. allergic Cutaneous vasculitis symptoms:
This disease involved only the skin, occur in young adults. General fatigue, joint symptoms such as muscle pain, a small number of cases may have irregular fever. Skin damage can be pleomorphic, with erythema, nodules, purpura, wind groups, blood blisters, papules, necrosis and ulcers. Knees for the most common to the two lower leg and foot up to the back skin lesions. More lesions are characterized by the beginning of purpura-like rash, pressure does not fade is the result of vessel wall inflammation and exudative cell infiltration, and they are high silt from the spot can be touched, is characteristic of allergic Cutaneous vasculitis. Some started to subcutaneous nodules, such as broad beans and soybeans to jujuba size, there is tenderness pink. Purpura may have started to complete the kind of lesions, and some may Erysipelas-like skin lesions began to change, and some may morphea-like changes, and some may like erythema multiforme. The development process in the skin lesions may be accompanied by the wind group, such as papules. As a result of severe inflammatory response in Henoch-Schonlein purpura and rash occurred in blood blisters, necrosis and ulcers, nodules as part of the damage may also occur with painful ulcers. Edema to the ankle and foot for the weight. More pronounced in the afternoon, accompanied by two lower limbs weakness. There are a variety of lesions of this disease, but almost every purpura or nodules. Neutral polynuclear leukocyte extravasation to the surrounding tissue can also occur when the pustules. Lesions can occur at any site, such as the back, upper limbs, buttocks, etc., the distribution was symmetrical. Lesions have a conscious pain, itching or burning sensation, and some without symptoms, and tenderness. After the lesions have more pigmentation and, if after the ulcer can become atrophic scars. Acute episode of disease, the damage to occur in batches, are widely distributed, with lower leg edema, severe illness. After damage from chronic, recurrent sustained a few months or years. Light lesions were 2 to 4 weeks may be more. Some lesions integration to become a large expansion of the damage around the knee, elbow and hands often, it seems erythema lasting performance uplift.
2. Systemic allergic vasculitis symptoms:
This disease with multiple organ involvement, severe illness. As the organ of small capillary blood vessels, especially vein involvement, so diffuse exudative lesions and bleeding in the organs of many. The performance of multi-organ involvement for the acute disease, often have symptoms include headaches, irregular fever, malaise, fatigue, joint and muscle pain. Different course of disease, the severity of different, if the first contact with antigen, about 3 to 4 weeks more, if repeated exposure to antigen, recurrent disease, the course lasted for several months or years. Prognosis of Systemic allergic vasculitis depends on the degree of involvement of organs and lesions.
67% of patients with pleomorphic skin damage, but often reach for the more common plaque deposition. 75% of patients have non-specific fever, about 2 / 3 of the section of patients with pain and swelling. Mucosal lesions may be violated, the occurrence of epistaxis, hemoptysis, hematochezia. 1 / 3 of patients with kidney involvement, with proteinuria hematuria, severe kidney failure is the leading cause of death. Intestinal violations may have abdominal pain, fatty dysentery, hematochezia, acute cholecystitis, such as gastrointestinal symptoms. Have pancreatitis, diabetes. Chest X-ray examination demonstrated pneumonia and nodular shadow, pleurisy or pleural effusion. Can be violations of the nervous system, if a headache, diplopia, paranoia, mental disorders, cerebral thrombosis and even paralysis, dysphagia, sensory and / or motor function disorders. Heart damage is myocardial infarction, cardiac rhythm disorders and pericarditis. Ischemic renal cortex may have serious high blood pressure. The most common systemic vasculitis of the ocular inflammation manifested as the outer sclera and retinal hemorrhage. Vice Clonorchis and painful swelling of the testicles may be a manifestation of vasculitis. Diagnosis of systemic vasculitis, including renal biopsy and direct immunofluorescence assay.