Allergic vasculitis Diagnosis

Allergic vasculitis is diagnosed by some tests include:

1, blood biochemical examination:
Allergic Cutaneous vasculitis in general no significant change. Systemic allergic vasculitis have anemia, platelet temporary reduced leukocytosis, 1 / 3 of patients with eosinophilia, generally 0.04 ~ 0.08, a small number of 0.56. urine protein and red blood cells, and occasional granular cast. in serious cases can be elevated BUN. more than half of patients with erythrocyte sedimentation rate can be faster. the total complement and complement C3, C4 can be reduced. IgG, IgA were increased, IgM lower, the change in line with the condition. in patients with liver function may be abnormal. circulating immune complexes were positive. The following laboratory tests are also meaningful to Allergic vasculitis, such as anti-nuclear antibody, serum test for syphilis, anti-chain "O", rheumatoid factor, cold ball such as protein and HBsAg. should also pay attention to potential infection and tumors, and at the same time pay attention to the observation of connective tissue disease.

2 Histopathological examination:
The main basis for its change in disease severity, disease duration and based on the situation at that time. Dermal capillaries under normal circumstances and the small blood vessels surrounded by inflammatory cell infiltration, there are more neutrophilic leukocyte infiltration and formation of neutrophil disintegration of many scattered pieces in the nuclear split, called the nuclear dust, at the same time organized cells and eosinophilic infiltration, strong perivascular staining eosinophilic fibrin deposition beam. in sections, due to the deposition of fibrin edema combined with the obvious, so that the perivascular collagen was the appearance of ambiguity, known as fiber-like degeneration. vascular endothelial cell swelling, such as severe may lead to lumen obstruction. inflammatory cells at the same time violations of the vessel wall, blood vessel wall mainly neutrophils violations, so that the vessel wall unclear, at the same time there may be eosinophilic leukocytes, a small number of mononuclear cells. wall beam deposition of fibrin and vascular necrosis. more red blood cell extravasation is common. histopathology of Allergic vasculitis mainly characterized by perivascular for of leukocyte infiltration, nuclear dust. exudation with red blood cells, inflammatory cell infiltration in the upper dermis, blood vessel wall has violated neutrophils, vascular and some vague and necrosis, perivascular and vascular wall-beam deposition of fibrin , ulcers are caused as a result of vascular necrosis, at the same time shows that the deposition of hemosiderin. in chronic cases with little or no red blood cell extravasation.

3, electron microscopy:
Can be found in violation of capillary vein, in particular, violations of 8 ~ 30μm size of blood vessels. Early for vascular endothelial cell swelling, fissures between the endothelial cells and macrophages active phenomenon, basement membrane thickening. Neutrophils in the interstitial blood vessels. re-platelet cohesion within the lumen and endothelial cells through.

4, direct immunofluorescence examination:
Vascular basement membrane may have IgA antibodies, dermis and subcutaneous tissue have IgM and IgG antibodies and complement C3 deposition. In its fixed-site destruction of composition can be found mainly in the fiber-like necrosis found in the region.