Allergic vasculitis Causes

The causes of Allergic vasculitis have many factors and complex, mainly caused by drugs and infections. The most common pathogenic type drugs include barbiturates, propofol thiazides, sulfonamides, penicillin, iodide category, Aspen aspirin and variant protein. Infection is also an important factor, such as viruses, Streptococcus, Mycobacterium tuberculosis, leprosy bacilli. Fungi and protozoa is also a risk factor of Allergic vasculitis. Pesticides, herbicides and petroleum products are related with this disease. In addition, the internal diseases, such as frozen protein hyperlipidemia, high hypergammaglobulinemia, systemic lupus erythematosus, rheumatoid arthritis also is cause Allergic vasculitis.

The majority factors are not directly pathogenic, and only the streptococcal M protein, Mycobacterium tuberculosis, hepatitis B antigen expression has been proved to be a direct pathogenic significance. These three antigens always have a corresponding antigen with its antibody in the blood vessels in the same way with the co-occurrence. When the protein antigen into the blood circulation, resulting in specific antibodies, especially IgG or IgM, antigen-antibody in the blood stream or in the organization of space in the formation of immune complexes, this complex deposition in the vessel wall and the surrounding tissues, activated by body generated C3 anaphylatoxin, causing the mast cells to release histamine to increase vascular permeability and to attract multi-leukocyte aggregation neutral immune complex deposition in parts, caused by inflammatory cell infiltration. Platelet and neutrophil adhesion in the surface of multi-core leukocyte immune complexes, complement so that combined with the re-activation of complement, caused by platelet and soluble interleukin-neutral multi-core, when the platelet and clotting factor release vasoactive substances, caused by fibrin deposition and hemorrhage , when the neutral polynuclear leukocyte collagenase release, stretch other hydrolase enzymes, which damage collagen fibers, elastic fibers, basement membrane and surrounding tissue, the blood vessel wall inflammatory cell infiltration, fibrin deposition vessel wall damage necrosis, caused by a variety of symptoms of vasculitis.